(An active ingredient is the part of the medication that makes it work. If you are in the donut hole coverage phase, your copay could vary between $5-$713. These foil strips hold Trelegy Elliptas active drugs as follows: Note: After you inhale a dose of Trelegy Ellipta, be sure to rinse your mouth with water and spit out the water without swallowing. How long does it take for Trelegy to work? If you take umeclidinium with another anticholinergic medication, the drugs effects can combine and increase your risk for side effects. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Both Trelegy Ellipta and Breo Ellipta are dry powder inhalers. Trelegy Ellipta: Basics, Side Effects & Reviews - GoodRx Accessed Oct. 21 at doi:10.1056/NEJMoa1713901, Trelegy Ellipta [Prescribing Information]. Note: Trelegy Ellipta is meant to be used over time to control COPD symptoms. The study showed that people who took Trelegy Ellipta were able to force out 97 mL more air in 1 second than people who took Breo Ellipta. In 2020, the FDA approved a third indication for Trelegy Ellipta for maintenance treatment of asthma in adults. Some drugs can prolong (lengthen) a part of your heart rhythm called the QT interval. For patients who do not respond adequately to Trelegy Ellipta 100/62.5/25 mcg once daily, increasing the dose to Trelegy Ellipta 200/62.5/25 mcg once daily may provide additional improvement in asthma control. Keep all medications away from children and pets. Hair testing is a reliable way to figure out long-term use of tobacco products and can be very accurate for as long as 1 to 3 months after you stop using tobacco. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. Only second day but extremely short of breath. Both Trelegy Ellipta and Breo Ellipta are approved for use in adults as long-term treatment of: However, Breo Ellipta is approved as a maintenance treatment for asthma only when: Note: Neither Trelegy Ellipta nor Breo Ellipta is approved to treat sudden trouble breathing. And this can cause the level of Trelegy Ellipta in your body to be too high, increasing your risk for side effects. However, the three drugs (fluticasone, umeclidinium, and vilanterol) in Trelegy Ellipta have been studied separately. Common medications that may interact with Trelegy Ellipta include: Always tell your doctor and pharmacist about all the medicines you take, including prescription medicines, over-the-counter drugs, vitamins, and herbal dietary supplements. Pulmonologist just switched me to Trelegy. This list contains examples of serious side effects that can occur with Trelegy Ellipta, with Breo Ellipta, or with both drugs (when taken individually): Trelegy Ellipta and Breo Ellipta are both approved to treat COPD and asthma in adults. These drugs havent been directly compared in clinical studies. * This strength of Trelegy Ellipta is abbreviated as 100/62.5/25 mcg. This can eventually cause vision loss if its not treated. Breo is a brand-name prescription medication. fluticasone, an inhaled corticosteroid that lowers inflammation and swelling in the lung airways, vilanterol, a long-acting beta-agonist (LABA) bronchodilator that relaxes the airway muscles to help open airways. However, your doctor will likely want you to have a rescue inhaler in case you have sudden breathing problems. With emphysema, your lungs are damaged and have trouble passing air in and out. Vilanterol, an ingredient in Trelegy Ellipta, is a LABA. Some people do feel or taste Trelegy Ellipta after taking it. How do I store Trelegy Ellipta? Some antimicrobial drugs inhibit (block) the activity of CYP3A4, which is an enzyme that breaks down Trelegy Ellipta. Trelegy Ellipta is not used as a fast-acting inhaler for the relief of acute breathing emergencies. Adverse Reactions | TRELEGY (fluticasone furoate, umeclidinium N Engl J Med. It depends on what types of eye problems you have. Use only your fast-acting inhalation medicine (for example, albuterol) for an attack. With asthma, you may have symptoms such as: Its important to note that Trelegy Ellipta is meant to be used over time to control asthma symptoms. Theres also a video on the manufacturers website that shows you the correct way to take Trelegy Ellipta. Trelegy Ellipta is a combination medication that contains three drugs: fluticasone, umeclidinium, and vilanterol. A medication timer may be useful, too. Therefore, these medications can cause some very similar side effects. For more information about this, see the Trelegy Ellipta use with other drugs section below. It is used once daily to help breathing symptoms and reduce the number of asthma or COPD flare-ups over the long-term. You should use Trelegy Ellipta at the same time each day. If your potassium level gets too low, you can have heart problems such as an irregular heart rhythm (a heartbeat thats too fast, too slow, or uneven). Trelegy Ellipta is a combination medication thats used to treat asthma. If you miss a dose of Trelegy Ellipta, take it as soon as you remember, and then take your next dose at your usual time. Dont use this medication more than once in 24 hours. Trelegy Ellipta is a medicine used to relieve the symptoms of moderate to severe chronic obstructive pulmonary disease (COPD). Learn about side effects, warnings, dosage, and more. Beta-blockers are common medications that help decrease blood pressure and steady your heart rhythm. The word Ellipta refers to the specific type of dry powder inhaler that contains the drug. It is the fast acting steroid and usually has a half-life around 2-3 days. Tell your doctor if you are pregnant, planning a pregnancy, breastfeeding or planning to breastfeed before you start treatment. ; Weakened immune system and increased chance of getting infections That means with a half-life of 5 days, it will likely take 27.5 days-almost a whole month-for the body to clear this drug. Last updated on Oct 4, 2022. Trelegy Ellipta is an option for the treatment of asthma in patients not controlled on inhaled corticosteroids and long-acting beta agonists alone. However, this doesnt mean that Trelegy Ellipta will be present in human breast milk. So in theory, its possible for Trelegy Ellipta to cause you to gain weight. They can advise you on the best way to feed your child. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Trelegy Ellipta is approved for use in adults ages 18 years and older. Trelegy Ellipta and Symbicort are both approved to treat COPD and asthma in adults. Trelegy is the brand name of the medication inside the inhaler. Trelegy Ellipta was studied in over 10,000 patients with symptomatic chronic obstructive pulmonary disease (COPD) and a history of prior exacerbations (flare-ups). With Trelegy Ellipta, there was a 97 mL improvement vs Breo and 54 mL improvement vs Anoro. COPD is a long-term disease in which the airways and air sacs inside the lungs become damaged or blocked, leading to difficulty breathing. For more details: See Dosage and Administration in the full Prescribing Information. If you have been using an oral steroid (corticosteroid) medication, you should not stop using it suddenly. Brand-name medications usually cost more than generics. All rights reserved. Certain antidepressant medications can interact with Trelegy Ellipta. You can use your rescue inhaler in between your doses of Trelegy Ellipta if you have flare-ups of COPD or asthma symptoms. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. It should be stored in a dry place and kept away from sunlight and heat. We simply charge $49 a month per medication to cover the cost of our services. If you think youve taken too much of this drug, call your doctor. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Trelegy Ellipta is used in adults whose disease is not controlled well enough with a combin ation of inhaled medicines consisting of a long-acting beta-2 agonist plus either a corticosteroid or a long- Serious side effects from Trelegy Ellipta arent common, but they can occur. Dosing & Delivery | TRELEGY (fluticasone furoate, umeclidinium There are currently no generic forms of either drug. Breo comes in a powder. Steady state occurred within 6 days of daily dosing. Seek emergency medical treatment or call 911 if your breathing problems get worse quickly. It is not used as a fast-acting rescue inhaler for sudden breathing problems. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Clinical studies with over 2,400 patients evaluated improvement in lung function as measured by the change from baseline in trough forced expiratory volume over one second (FEV1) at 24 weeks of treatment. The combination of these medications can cause a problem with your heart rhythm. If you need financial support to pay for Trelegy Ellipta, help is available. Symptoms of a severe allergic reaction can include: Call your doctor right away if you have a severe allergic reaction to Trelegy Ellipta. No preparation or checks of the inhaler are required. Specifically, its important to avoid taking monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants while youre using Trelegy Ellipta. Trelegy Ellipta contains fluticasone, which is an inhaled steroid. Can poor sleep impact your weight loss goals? Because of these actions, they work together to decrease COPD or asthma symptoms and make it easier for patients to breathe. How long does Trulicity stay in your system? If you develop symptoms of thrush, be sure to see your doctor. In studies, Trelegy has shown a positive effect on breathing tests (FEV1) with the first dose, but it may take several weeks or longer for your overall symptoms to improve in COPD or asthma. Once opened, the inhaler is only good for 6 weeks. Trelegy is the name of the medication inside the inhaler. When you open the tray that contains Trelegy Ellipta, write the date that you opened it on the label of the inhaler. Other combination medications that may be used to treat COPD include: Other medications that may be used to treat COPD include: Note: Trelegy Ellipta and the alternative drugs listed here are meant to be used over time to control COPD symptoms. (For more about possible side effects of Trelegy Ellipta, see the Trelegy Ellipta side effects section above.) Ask your doctor what other treatments are better choices for you. They can recommend medication to treat the current infection. This medication is also metabolized hepatically. The Food and Drug Administration (FDA) approves prescription drugs such as Trelegy Ellipta to treat certain conditions. For example, it can differ whether you're taking an inhaled medication such as Advair (fluticasone and salmeterol) or an oral corticosteroid (e.g., prednisone ). Slide. There are currently no generic forms of either drug. Follow your doctor's instructions about tapering your dose. Vilanterol is a long-acting beta2-agonist (LABA). umeclidinium, a long-acting muscarinic antagonist (LAMA), an anticholinergic bronchodilator that helps to block muscle tightening around your airways to improve breathing. Symbicort comes as a metered dose inhaler. It is primarily metabolized via CYP3A4 and is also a substrate of P-glycoprotein transporter. Drugs.com. Speak to your doctor or pharmacist about how drug interactions should be managed. Trelegy is the brand name of the medication inside the inhaler. Trelegy Ellipta fluticasone furoate 100 mcg / umeclidinium 62.5 mcg / vilanterol 25 mcg inhalation powder (medicine). However, babies whose mothers were given vilanterol while pregnant did have birth defects affecting their bones. If you drink alcohol, talk with your doctor whether its safe for you to continue drinking while youre taking Trelegy Ellipta. However, in rats it is believed that pro-inflammatory transcription factors are inhibited along with antigen-induced lung eosinophilia. Medically reviewed by Leigh Ann Anderson, PharmD. Its not currently available in generic form. The actual price youll pay depends on your insurance plan, your location, and the pharmacy you use. Its not known if Trelegy Ellipta is safe to take while breastfeeding. Trelegy Ellipta contains lactose, which is a type of sugar in milk. Youll take one inhalation (puff) of Trelegy Ellipta once a day. Fluticasone furoate has a very low oral systemic bioavailability, about 1.3%. Bronchodilation is important in the treatment of COPD or asthma, as it helps to let more air into the lungs and allows for easier breathing. There were no overdoses reported in people who took Trelegy Ellipta in clinical studies. Revision date: October 4, 2022. prednisone, Symbicort, Breo Ellipta, Xopenex, Anoro Ellipta, Atrovent, Dulera, Stiolto Respimat, Nucala. Because it contains three medicines, it may be useful for those on a fixed-dose combination of fluticasone / vilanterol (Breo Ellipta) who need added bronchodilation, or those who are already using Breo Ellipta and Incruse Ellipta (umeclidinium) as 2 separate medicines. Trelegy Ellipta is meant to be used as a long-term treatment. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. Read and follow all patient instructions provided with the inhaler device. If you have sudden trouble breathing, your doctor will likely want you to use a rescue inhaler such as albuterol (Ventolin HFA, ProAir) or levalbuterol (Xopenex). mild allergic reaction *. They may be able to recommend ways to help prevent headaches from occurring. Other drugs that may prolong your QT interval include: If you take any of these medications or other drugs for your heart rhythm, talk with your doctor before you start Trelegy Ellipta treatment. Blocking these mediators can also decrease inflammation in the airways. Together, these drugs work in the body to decrease inflammation and increase the space in the airways to allow more air into the lungs. Benzodiazepines and MDMA generally flag a urine test for up to 4 days after last dose. In these animal studies, there were no harmful effects on babies whose mothers were given fluticasone or umeclidinium while pregnant. your medical condition and treatment and ask if there is any new information about TRELEGY ELLIPTA. In asthma patients: common cold symptoms (13% to 15%), rhinitis (runny or stuffy nose), painful and frequent urination (signs of a urinary tract infection), upper respiratory tract infection (3% to 6%), bronchitis (3% to 5%), flu, respiratory tract infection, headache (5% to 9%), inflammation of the sinuses, and back pain. Tell them about all prescription, over-the-counter, and other drugs you take. Trelegy Ellipta is made of three medications that work to help ease the symptoms of COPD. Research Triangle Park, NC: GlaxoSmithKline. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Based on a survey for secondary outcomes, Trelegy also improved patients health-related quality of life when compared to Breo, which included items such as daily symptoms, daily activities and perceived well-being. Other combination medications that may be used to treat asthma include: Other medications that may be used to treat asthma include: Note: Trelegy Ellipta and the alternative drugs listed here are meant to be used over time to control asthma symptoms. Your doctor knows your medical condition the best and can give you a timeline of your treatment response. cough. Trelegy Ellipta comes as an inhaler. This is because it can take time for the medications in Trelegy Ellipta to begin working. And youll usually keep coughing up mucus. If you and your doctor determine that Trelegy Ellipta is safe and effective for you, youll likely take it long term. Fluticasone is an inhaled steroid medication. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Trelegy Ellipta is a long-term treatment that will work over time to ease COPD and asthma symptoms and help you breathe easier. Once opened, the tray is good for only 6 weeks. They can recommend ways to help ease the pain. This can cause you to breathe in too much medication, which may be harmful to you. For patients who do not respond adequately to TRELEGY 200 once daily, re-evaluate and consider other therapeutic regimens and additional therapeutic options. The experts say that at least 16 million Americans suffer with this challenging breathing problem. The three active drugs in Trelegy Ellipta are fluticasone, umeclidinium, and vilanterol. The drug comes as an inhaler, Chronic obstructive pulmonary disease (COPD) is an umbrella term for conditions that cause airflow and breathing difficulties. The drugs are fluticasone, umeclidinium, and vilanterol. * This is a partial list of mild side effects from Trelegy Ellipta. Ask your doctor or pharmacist if you do not understand these instructions. This is an inhaler that dispenses the drug as a spray, which you breathe into your lungs. However, be sure to take the dosage your doctor prescribes for you. This can cause wheezing and fatigue (lack of energy). There arent any herbs or supplements that have been specifically reported to interact with Trelegy Ellipta. If you have a severe protein milk allergy, you shouldnt use Trelegy Ellipta. The drug vilanterol may relax the uterus, which can prevent contractions and cause problems during labor and delivery. You can find an updated list of ingredients at the end of the manufacturers patient information. Examples of tricyclic antidepressants include: If youre taking an antidepressant, talk with your doctor before you start using Trelegy Ellipta. You may wonder how often certain side effects occur with this drug, or whether certain side effects pertain to it. In comparison, back pain only occurred in about 1% to 4%* of people who took only fluticasone and vilanterol (two of the three ingredients in Trelegy Ellipta). Asthma is a lung condition that makes it hard to breathe due to swelling and narrowing in your airways. Only open the tray when youre ready to start using the inhaler so you can use all of the doses before the inhaler expires. Trelegy Ellipta can cause mild or serious side effects. Instead, youll use a rescue inhaler for sudden trouble breathing. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Because Trelegy Ellipta can also decrease your potassium level, the combination of these medications can be dangerous. Trelegy Ellipta is approved for both the once-daily treatment of adults with chronic obstructive pulmonary disease (COPD) or asthma. The drug should not be used to treat acute bronchospasm associated with either COPD or asthma. Alcohol may also weaken the activity of your immune system, making it easier for you to get an infection. If youre breastfeeding, talk with your doctor before taking Trelegy Ellipta. The studies also showed that asthma exacerbations (flare-ups of asthma symptoms) occurred in: Other drugs are available that can treat your condition. In studies, Trelegy has shown a positive effect on breathing tests (FEV1) with the first dose, but it may take several weeks or longer for your overall symptoms to improve in COPD or asthma. To keep track of how long you have been using this medicine, write the date of when you open the tray on inhaler label. Available for Android and iOS devices. Trelegy Ellipta Coupon & Prices - Cost $49 per month - NiceRx Heres some information about the forms of each drug and how you take them. The exact way that fluticasone works to decrease inflammation is not known. If you have any questions about eating certain foods with Trelegy Ellipta, talk with your doctor. ICS medicines work by decreasing lung inflammation (swelling) that can cause breathing problems. Its effects are seen through the inhibition of M3 receptors, which leads to bronchodilation. You may be able to. The safety of TRELEGY ELLIPTA in COPD is based on the safety data from two 12-week treatment trials with coadministration of umeclidinium and the fixed-dose combination of fluticasone furoate/vilanterol and a 52-week long-term trial of TRELEGY ELLIPTA 100/62.5/25 mcg compared with the fixed-dose combinations of fluticasone furoate/vilanterol . May 2019. If you have sudden trouble breathing, your doctor will likely want you to use a rescue inhaler such as albuterol (Ventolin HFA, ProAir) or levalbuterol (Xopenex). Below are examples of these side effects. Trelegy Ellipta is approved in two strengths for use in asthma: 100/62.5/25 mcg and 200/62.5/25 mcg, while only the 100/62.5/25mcg strength is approved in COPD. Tell your doctor if you have glaucoma or elevated eye pressure before you start treatment. In clinical trials, Trelegy Ellipta was effective in treating COPD. Therefore, an overdose isnt likely to occur. Trelegy Ellipta is NOT a fast-acting rescue medicine to be used during a sudden breathing attack in COPD or asthma. The combination of fluticasone and vilanterol has been studied as well. This medication works mainly in your lungs and isnt absorbed well into your body. Steroids can increase your level of cortisol, which is a hormone that has effects on your metabolism. Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD. Lung function improvements (change from baseline in trough forced expiratory volume over one second [FEV1] at month 12) were also significant in the study. The word Ellipta refers to the specific type of dry powder inhaler that contains the drug. Your doctor or pharmacist may also be able to recommend ways to help prevent a thrush infection from occurring in the future. This is compared with 3% to 7%* of people who took only fluticasone and vilanterol (two of the three ingredients in Trelegy Ellipta). Umeclidinium is minimally orally absorbed. For patients who do not respond adequately to TRELEGY ELLIPTA 100/62.5/25 mcg once daily, increasing the dose to TRELEGY ELLIPTA 200/62.5/25 mcg once daily may provide additional improvement in asthma control. Trelegy Ellipta: Side Effects, Dosage, Use for COPD, and More - Healthline unpleasant or unusual taste in your mouth. If you have questions about how to treat sudden breathing problems while taking Trelegy Ellipta, talk with your doctor. constipation. Symbicort has two active drug ingredients in it: budesonide and formoterol. Trelegy is used once daily in adults with either asthma or COPD to help breathing symptoms and reduce the number of flare-ups by lowering the swelling in your lungs and relaxing your airways. A diuretic (water pill) helps your body get rid of extra water and salt. For information about this, see the Trelegy Ellipta use with other drugs section below. Fluticasone furoate is metabolized mainly by cytochrome P450 (CYP) 3A4. Trelegy Ellipta (generic name: fluticasone furoate / umeclidinium / vilanterol) is an inhaler for asthma or COPD and must be used daily to be effective. Trelegy Ellipta (Fluticasone furoate 100 or 200 micrograms Its available only as a brand-name medication. You can take Trelegy Ellipta in the morning, afternoon or the evening, just be sure to take it at the same time each day. The half-life of fluticasone furoate is about 24 hours. For information about this, see the Trelegy Ellipta use with other drugs section below. This helps prevent others, including children and pets, from taking the drug by accident. Trelegy Ellipta can interact with several other medications. After an intravenous dose, 58% is excreted in the feces and 22% is excreted in the urine. Accessed Oct, 22, 2020 at https://www.drugs.com/newdrugs/fda-approves-trelegy-ellipta-fluticasone-furoate-umeclidinium-vilanterol-asthma-5350.html. sore throat. Symptoms of thrush include mouth pain or white patches in the mouth. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. Most inhaled steroids have a beneficial effect for 12 hours. stomach flu. Mild side effects* of Trelegy Ellipta can include: Most of these side effects may go away within a few days or a couple of weeks. COPD is a long-term lung disease that includes chronic bronchitis, emphysema, or both. Trelegy is approved as a maintenance (long-term) medicine for use in either chronic obstructive pulmonary disease (COPD) or asthma in adults. These allergic reactions can be serious. If the drug does cause side effects, you may have: A vilanterol overdose may include serious symptoms, such as: Because these medications can affect the heart, your doctor will monitor your heart if you take too much Trelegy Ellipta. How Long Does Trenbolone Takes Times To Stay In Your System? According to GoodRx, if you are in the post-deductible phase, your copay could range between $0-$713. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Trelegy Ellipta only for the indication prescribed. For more information, see the Trelegy Ellipta for asthma section below. Heres some detail on a few of the side effects this drug may or may not cause. Trelegy Ellipta should be discarded in the trash 6 weeks after first use OR when the counter reads 0 (which means you are out of medicine), whichever occurs first. (A generic drug is an exact copy of the active drug in a brand-name medication.). The word "Ellipta" refers to the specific type of dry powder inhaler that contains the drug. Never take two doses at once to try to make up for a missed dose. COPD is a group of lung conditions that include chronic bronchitis and emphysema, and it can cause wheezing, coughing, and trouble breathing. Trelegy Ellipta hasnt been studied in pregnant animals either. The following lists contain some of the key side effects that may occur while taking Trelegy Ellipta. 4. The following information is provided for clinicians and other healthcare professionals. Trelegy Ellipta Side Effects: Common, Severe, Long Term - Drugs.com How Long Do Steroids Stay in Your System? - Verywell Health Heart failure: Could a low sodium diet sometimes do more harm than good? The drug isnt meant to be used for sudden breathing problems caused by COPD. Each person's response to medicine can be different. This may cause the anti-inflammatory effects that are seen with fluticasone treatment. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. With NiceRx, you'll only pay $49 to obtain your Trelegy Ellipta, regardless of the retail price. We comply with the HONcode standard for trustworthy health information. Learn more here. These lists contain examples of mild side effects that can occur with Trelegy Ellipta, with Symbicort, or with both drugs (when taken individually). Heres a comparison of how Trelegy Ellipta and Symbicort are alike and different. While youre taking Trelegy Ellipta, its important that you go for regular eye exams. And dont swallow the water that you rinse with. Over one year, triple therapy with Trelegy was shown to improve rates of COPD flare-ups, improve lung function (FEV1), quality of life and rates of hospitalizations when compared to dual therapy such as Breo Ellipta (fluticasone and vilanterol) or Anoro Ellipta (umeclidinium and vilanterol). In studies of patients with asthma, a significant improvement in lung function (FEV-1) was seen at 24- and 52-weeks when compared to the use of Breo (fluticasone and vilanterol). Trelegy Ellipta contains three different drugs (fluticasone, umeclidinium, and vilanterol), so you usually wont need to take another maintenance medication along with it. These lists dont include all possible side effects. For more information about what these drugs do, see the How Trelegy Ellipta works section below. If you would like to report to the FDA a side effect youve had with Trelegy Ellipta, you can do so through MedWatch. Trelegy Ellipta and Symbicort both contain medications that work in similar ways to treat your COPD. Before taking Trelegy Ellipta, talk with your doctor about your health history. Taking too much umeclidinium isnt likely to cause you any serious side effects. Instead, youll use a rescue inhaler for sudden trouble breathing. Finally, babies whose mothers were given the combination of fluticasone and vilanterol didnt have an increased risk of birth defects. The maximum recommended dosage is 1 inhalation of TRELEGY ELLIPTA 200/62.5/25 mcg once daily.

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